REcreating the ideal Niche: environmental control Of cell Identity in Regenerating and diseased muscles
RENOIR is a European Training Network that aims to develop and implement a PhD programme in the field of muscle regeneration and aging.
Indeed, one of the major challenges in Europe for the coming decades is to have an ageing population, which is healthy and active, and to improve the quality of life of people affected by chronic diseases, ultimately providing a positive impact in productivity and competitiveness.
The major objective of RENOIR research programme is to ultimately unravel, using novel and integrated biotechnological tools, the progressive decline in skeletal and cardiac muscle mass and functionality, that represents the most critical and complex features associated with human ageing and disease.
Many of the pathological features of muscle degenerative diseases and aging are not only caused by the loss of function of structural proteins and/or the failure of muscle stem cells.
They are also due to the complex interactions of these cells with the surrounding environment that, when altered, can delay muscle repair and regeneration, modulate the inflammatory response, thus leading to disease exacerbation and fibrosis development.
A critical role in controlling these processes has been revealed also for physical and mechanical factors. Hence being such a multi-disciplinary endeavour, how the overall process is regulated is far from being fully elucidated, thus hampering therapeutic strategies.
RENOIR is a European Training Network that brings together 9 academic and 6 non-academic participants.
The multi-disciplinary research approach of RENOIR include both academic and industrial experts in the field of muscle regeneration, stem cells, aging and bioengeneering.