RENOIR

REcreating the ideal Niche: environmental control Of cell Identity in Regenerating and diseased muscles

Renoir itn

RENOIR is a European Training Network that aims to develop and implement a PhD programme in the field of muscle regeneration and aging.

Indeed, one of the major challenges in Europe for the coming decades is to have an ageing population, which is healthy and active, and to improve the quality of life of people affected by chronic diseases, ultimately providing a positive impact in productivity and competitiveness.

The major objective of RENOIR research programme is to ultimately unravel, using novel and integrated biotechnological tools, the progressive decline in skeletal and cardiac muscle mass and functionality, that represents the most critical and complex features associated with human ageing and disease.

Many of the pathological features of muscle degenerative diseases and aging are not only caused by the loss of function of structural proteins and/or the failure of muscle stem cells.

They are also due to the complex interactions of these cells with the surrounding environment that, when altered, can delay muscle repair and regeneration, modulate the inflammatory response, thus leading to disease exacerbation and fibrosis development.

A critical role in controlling these processes has been revealed also for physical and mechanical factors. Hence being such a multi-disciplinary endeavour, how the overall process is regulated is far from being fully elucidated, thus hampering therapeutic strategies.

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OUR CONSORTIUM

Renoir

RENOIR is a European Training Network that brings together 9 academic and 6 non-academic participants.

The multi-disciplinary research approach of RENOIR include both academic and industrial experts in the field of muscle regeneration, stem cells, aging and bioengeneering.

Beneficiaries

Unimib logo

University of Milano – Bicocca

 Italy

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IGB CNR

IGB-CNR Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche

Italy

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Lyon 1

University Claude Bernard Lyon 1

France

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Pompeu Fabra University

Pompeu Fabra University

Spain

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University of Manchester

University of Manchester

United Kingdom

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University of Debrecen

University of Debrecen

Hungary

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Fondazione Santa Lucia

Fondazione Santa Lucia

Italy

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University of Naples

University of Naples

Italy

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King’s College London

King’s College London

United Kingdom

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Eden Microfluidics

Eden Microfluidics

France

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Technion Israel Institute of Technology

Technion Research & Development Foundation Ltd.

Israel

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HMGBiotech S.r.l.

Italy

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Cherry Biotech

Cherry Biotech

France

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Partner Organisations

Parent Project ONLUS

Italy

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Italfarmaco

Italfarmaco

Italy

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Only by combining different and complementary competences, bridging biological science and engineering we will be able to shed light on the multi-layered connections occurring during tissue remodelling in the healthy, pathological and aging muscle

This will lead to new and successful approaches to modulate the host microenvironment to finally optimize tissue regeneration

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RENOIR

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