ESR10

Microfluidic bioreactor for high control over fluid and reagent delivery.

I received my Masters of Biomedical Engineering (MEng) from the University of Strathclyde in Glasgow, Scotland. During this time I studied a broad range of engineering and biomedical concepts, from electronics design to immunology. My academic projects included developing electrochemical biosensors and microfluidic devices for cell culture.

On graduating in June 2020 I undertook an internship at MIMETAS Organ-On-A-Chip company in Leiden, The Netherlands. I was a member of the Hardware R&D department developing and testing microfluidic prototypes.

It was this experience in microfluidics which led me to join Eden Tech in Paris as ESR10 within the Renoir consortium. I will be enrolled in the PhD program in Translational and Molecular Medicine (DIMET) at the

University of Milano-Bicocca. My project focuses on the design of a bioreactor with controlled circulation of fluid, with the aim to culture and stimulate muscle cells. This model will allow us to assess the effects of cell/cell interactions.

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Eden Tech

France

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Topic

Several studies support the emerging concept that inflammation controls stem cell fate/behaviour coordinating tissue repair and this balance is probably skewed in patients with late phases of chronic diseases, like muscle dystrophies and in aging. We will focus on how the inflammatory, myogenic and vascular components integrate to coordinate muscle regeneration and how fibrosis develops in pathological conditions.

This will allow the identification of critical cell mediators and key factors produced by them that could be exploited in the cell and pharmacological therapy of muscle diseases.

We will use microfluidic devices to control and modulate the cellular environment with the ultimate goal to reconstruct the muscle niche in vitro.

Crucial technologies that will be used and developed are microfluidic devices to control the cellular environment. Taking advantages of EDEN material technology and expertise, the microfluidic device will be made using the most suited material (Flexdym, PDMS, PMMA,…) for the targeted applications and features.

Objectives
  • To create a bioreactor with circulating fluid for culture and stimulation of cells

  • To develop a network of bioreactor for indirect culture of cells to assess the effects of cell/cell interaction

PHD Program

Ph.D. Programme in Translational and Molecular Medicine (DIMET),

University of Milano Bicocca

Supervisor

Cécile Perrault

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